node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acn | gdh | cg1737 | cg2280 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | 0.450 |
acn | gltA | cg1737 | cg0949 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | CITRATE SYNTHASE. | 0.981 |
acn | gltB | cg1737 | cg0229 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | GLUTAMINE 2-OXOGLUTARATE AMINOTRANSFERASE LARGE SU. | 0.686 |
acn | icd | cg1737 | cg0766 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | ISOCITRATE DEHYDROGENASE; Belongs to the monomeric-type IDH family. | 0.973 |
acn | mdh | cg1737 | cg2613 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | MALATE DEHYDROGENASE OXIDOREDUCTASE PROTEIN; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Almost equally active both for NADH and NADPH on the bases of the kcat values at pH 6.5, but catalytic efficiency for oxaloacetate reduction is 50-fold higher with NADH. | 0.698 |
acn | odhA | cg1737 | cg1280 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | 0.826 |
acn | prpC1 | cg1737 | cg0798 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | (METHYL)CITRATE SYNTHASE; Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with propionyl-CoA but with a lower specificity. | 0.900 |
acn | prpC2 | cg1737 | cg0762 | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | METHYLCITRATE SYNTHASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity. | 0.833 |
gdh | acn | cg2280 | cg1737 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | 0.450 |
gdh | gltA | cg2280 | cg0949 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | CITRATE SYNTHASE. | 0.904 |
gdh | gltB | cg2280 | cg0229 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | GLUTAMINE 2-OXOGLUTARATE AMINOTRANSFERASE LARGE SU. | 0.999 |
gdh | icd | cg2280 | cg0766 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | ISOCITRATE DEHYDROGENASE; Belongs to the monomeric-type IDH family. | 0.922 |
gdh | mdh | cg2280 | cg2613 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | MALATE DEHYDROGENASE OXIDOREDUCTASE PROTEIN; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Almost equally active both for NADH and NADPH on the bases of the kcat values at pH 6.5, but catalytic efficiency for oxaloacetate reduction is 50-fold higher with NADH. | 0.853 |
gdh | odhA | cg2280 | cg1280 | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | 0.952 |
gltA | acn | cg0949 | cg1737 | CITRATE SYNTHASE. | ACONITASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2- methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). ECO:0000250|UniProtKB:Q8ZP52, ; Belongs to the aconitase/IPM isomerase family. | 0.981 |
gltA | gdh | cg0949 | cg2280 | CITRATE SYNTHASE. | NADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. | 0.904 |
gltA | gltB | cg0949 | cg0229 | CITRATE SYNTHASE. | GLUTAMINE 2-OXOGLUTARATE AMINOTRANSFERASE LARGE SU. | 0.915 |
gltA | icd | cg0949 | cg0766 | CITRATE SYNTHASE. | ISOCITRATE DEHYDROGENASE; Belongs to the monomeric-type IDH family. | 0.883 |
gltA | ldh | cg0949 | cg3219 | CITRATE SYNTHASE. | L-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.823 |
gltA | mdh | cg0949 | cg2613 | CITRATE SYNTHASE. | MALATE DEHYDROGENASE OXIDOREDUCTASE PROTEIN; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Almost equally active both for NADH and NADPH on the bases of the kcat values at pH 6.5, but catalytic efficiency for oxaloacetate reduction is 50-fold higher with NADH. | 0.992 |