node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0107 | Cgl0721 | cg0141 | cg0828 | Glyoxalase/Bleomycin resistance protein/Dioxygenas. | Putative dihydrofolate reductase. | 0.418 |
Cgl0721 | Cgl0107 | cg0828 | cg0141 | Putative dihydrofolate reductase. | Glyoxalase/Bleomycin resistance protein/Dioxygenas. | 0.418 |
Cgl0721 | Cgl0722 | cg0828 | cg0829 | Putative dihydrofolate reductase. | Lactoylglutathione lyase or related lyase. | 0.625 |
Cgl0721 | folC | cg0828 | cg2608 | Putative dihydrofolate reductase. | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | 0.549 |
Cgl0721 | glyA | cg0828 | cg1133 | Putative dihydrofolate reductase. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.679 |
Cgl0721 | metF | cg0828 | cg2383 | Putative dihydrofolate reductase. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.412 |
Cgl0721 | sigB | cg0828 | cg2102 | Putative dihydrofolate reductase. | RNA POLYMERASE SIGMA FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.466 |
Cgl0721 | thyA | cg0828 | cg0966 | Putative dihydrofolate reductase. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.996 |
Cgl0721 | thyX | cg0828 | cg2162 | Putative dihydrofolate reductase. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.983 |
Cgl0722 | Cgl0721 | cg0829 | cg0828 | Lactoylglutathione lyase or related lyase. | Putative dihydrofolate reductase. | 0.625 |
folC | Cgl0721 | cg2608 | cg0828 | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | Putative dihydrofolate reductase. | 0.549 |
folC | glyA | cg2608 | cg1133 | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.655 |
folC | thyA | cg2608 | cg0966 | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.971 |
glyA | Cgl0721 | cg1133 | cg0828 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative dihydrofolate reductase. | 0.679 |
glyA | folC | cg1133 | cg2608 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | 0.655 |
glyA | metF | cg1133 | cg2383 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.977 |
glyA | thyA | cg1133 | cg0966 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.976 |
glyA | thyX | cg1133 | cg2162 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.971 |
metF | Cgl0721 | cg2383 | cg0828 | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | Putative dihydrofolate reductase. | 0.412 |
metF | glyA | cg2383 | cg1133 | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |