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mrx1 mrx1 gor gor trxB1 trxB1 msrA msrA trxC trxC mca mca Cgl2425 Cgl2425 arsC2 arsC2 cysQ cysQ folA folA thyA thyA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mrx1Glutaredoxin or related protein; Involved in defense against toxic arsenate. Involved in the mycothiol/myoredoxin redox pathway which uses a mycothioltransferase mechanism; functions as a monothiol mixed disulfide reductase and is recycled by a second mycothiol forming mycothione which in turn is reduced in a NADPH-dependent manner. (79 aa)    
Predicted Functional Partners:
gor
PUTATIVE GLUTATHIONE REDUCTASE.
  
 
 0.983
trxB1
THIOREDOXIN.
  
  
 0.977
msrA
PEPTIDE METHIONINE SULFOXIDE REDUCTASE; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
  
 
 0.972
trxC
THIOREDOXIN; Belongs to the thioredoxin family.
  
  
 0.954
mca
Uncharacterized proteins, LmbE homolog; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
   
 0.894
Cgl2425
Putative dithiol-disulfide isomerase involved in polyketide biosynthesis.
  
  
 0.843
arsC2
Arsenite efflux pump ACR3 or related permease; Catalyzes the proton motive force-dependent arsenite efflux from the cell. Probably functions as an arsenite/H(+) antiporter. Does not transport antimonite.
     
 0.833
cysQ
3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase.
 
     0.831
folA
DIHYDROFOLATE REDUCTASE.
  
    0.827
thyA
PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
    0.827
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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