node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0721 | folC | cg0828 | cg2608 | Putative dihydrofolate reductase. | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | 0.549 |
Cgl0721 | glyA | cg0828 | cg1133 | Putative dihydrofolate reductase. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.679 |
Cgl0721 | thyA | cg0828 | cg0966 | Putative dihydrofolate reductase. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.996 |
Cgl0721 | thyX | cg0828 | cg2162 | Putative dihydrofolate reductase. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.983 |
cysQ | folA | cg0967 | cg0965 | 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase. | DIHYDROFOLATE REDUCTASE. | 0.848 |
cysQ | thyA | cg0967 | cg0966 | 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.930 |
dcd | dut | cg3155 | cg2086 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.923 |
dcd | thyA | cg3155 | cg0966 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.925 |
dcd | tmk | cg3155 | cg0861 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.773 |
dut | dcd | cg2086 | cg3155 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.923 |
dut | thyA | cg2086 | cg0966 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.979 |
dut | thyX | cg2086 | cg2162 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.960 |
dut | tmk | cg2086 | cg0861 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.935 |
folA | cysQ | cg0965 | cg0967 | DIHYDROFOLATE REDUCTASE. | 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase. | 0.848 |
folA | folC | cg0965 | cg2608 | DIHYDROFOLATE REDUCTASE. | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | 0.956 |
folA | glyA | cg0965 | cg1133 | DIHYDROFOLATE REDUCTASE. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
folA | thyA | cg0965 | cg0966 | DIHYDROFOLATE REDUCTASE. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
folA | thyX | cg0965 | cg2162 | DIHYDROFOLATE REDUCTASE. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.999 |
folA | tmk | cg0965 | cg0861 | DIHYDROFOLATE REDUCTASE. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.763 |
folC | Cgl0721 | cg2608 | cg0828 | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. | Putative dihydrofolate reductase. | 0.549 |