STRINGSTRING
menG menG Cgl1290 Cgl1290 prpB2 prpB2 prpB1 prpB1 Cgl0203 Cgl0203 aceA aceA Cgl0926 Cgl0926 ilvB ilvB prpD2 prpD2 prpD1 prpD1 Cgl0923 Cgl0923
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
menGS-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLT; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). (168 aa)    
Predicted Functional Partners:
Cgl1290
2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE.
     
 0.707
prpB2
PROBABLE METHYLISOCITRIC ACID LYASE; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate; Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
     
 0.641
prpB1
PROBABLE METHYLISOCITRIC ACID LYASE; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
  
  
 0.637
Cgl0203
QUINONE OXIDOREDUCTASE.
   
  
 0.570
aceA
ISOCITRATE LYASE; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
 
  
 0.546
Cgl0926
Putative membrane protein.
  
    0.530
ilvB
ACETOLACTATE SYNTHASE.
      
 0.493
prpD2
PROPIONATE CATABOLISM PROTEIN PRPD; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer 2-methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity); Belongs to the PrpD family.
      
 0.477
prpD1
PROPIONATE CATABOLIC PROTEIN PRPD; Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer 2-methyl-aconitate; Belongs to the PrpD family.
   
  
 0.471
Cgl0923
PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR.
       0.470
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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