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lysG lysG lysE lysE Cgl2915 Cgl2915 lcpB lcpB Cgl1174 Cgl1174 Cgl1992 Cgl1992 gluC gluC Cgl1565 Cgl1565 hisG hisG fur fur benA benA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lysGTRANSCRIPTIONAL REGULATOR, LYSR FAMILY; Positively regulates the expression of the exporter LysE. Induction requires the presence of a coinducer, which is either intracellular L-lysine, L-arginine or L-citrulline. L-histidine also acts as coinducer of lysE expression, but this amino acid is not exported by LysE. The lysEG system prevents bacteriostasis due to elevated L-lysine or L-arginine concentrations that arise during growth in the presence of peptides or in mutants possessing a deregulated biosynthesis pathway ; Belongs to the LysR transcriptional regulatory family. (290 aa)    
Predicted Functional Partners:
lysE
Lysine efflux permease; Catalyzes the efflux of L-lysine. Can also export L- arginine and L-citrulline. The lysEG system prevents bacteriostasis due to elevated L-lysine or L-arginine concentrations that arise during growth in the presence of peptides or in mutants possessing a deregulated biosynthesis pathway. In vitro, can also export D-lysine during biotechnological production of D-amino acids.
 
  
 0.994
Cgl2915
Bacterial regulatory proteins, GntR family.
   
  
 0.747
lcpB
Cell envelope-related transcriptional regulator.
   
    0.718
Cgl1174
Bacterial regulatory proteins, crp family.
   
  
 0.697
Cgl1992
ABC-type peptide transport system, permease component.
   
  
 0.614
gluC
GLUTAMATE PERMEASE; Part of the binding-protein-dependent transport system for glutamate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
   
  
 0.584
Cgl1565
Predicted transcriptional regulator.
   
    0.563
hisG
ATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
   
  
 0.509
fur
FERRIC UPTAKE REGULATION PROTEIN; Belongs to the Fur family.
   
  
 0.500
benA
BENZOATE 1,2-DIOXYGENASE ALPHA SUBUNIT (AROMATIC RING HYDROXYLATION DIOXYGENASE A).
   
  
 0.491
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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