STRINGSTRING
thiF thiF thiG thiG Cgl0215 Cgl0215 thiD1 thiD1 thiS thiS Cgl1067 Cgl1067 nifS1 nifS1 Cgl0208 Cgl0208 moaE moaE thiE thiE thiC thiC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thiFDinucleotide-utilizing enzyme involved in thiamine biosynthesis. (358 aa)    
Predicted Functional Partners:
thiG
THIAMIN BIOSYNTHESIS PROTEIN; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.996
Cgl0215
PUTATIVE MOLYBDOPTERIN CONVERTING FACTOR.
  
 0.976
thiD1
PHOSPHOMETHYLPYRIMIDINE KINASE / HYDROXYMETHYLPYRI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the N-terminal section; belongs to the thiamine- phosphate synthase family. In the C-terminal section; belongs to the thiaminase-2 family.
  
  
 0.968
thiS
Sulfur transfer protein involved in thiamine biosynthesis.
  
 
 0.960
Cgl1067
Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme.
  
 0.956
nifS1
PROBABLE PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASE/CYSTEINE DESULFINASE.
  
 0.956
Cgl0208
HESA/MOEB/THIF FAMILY PROTEIN.
 
  
0.935
moaE
MOLYBDOPTERIN SYNTHASE, LARGE SUBUNIT.
 
 0.921
thiE
THIAMIN-PHOSPHATE PYROPHOSPHORYLASE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.883
thiC
THIAMINE BIOSYNTHESIS PROTEIN; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.881
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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