STRINGSTRING
hisA hisA hisI hisI hisF hisF hisH hisH hisB hisB trpCF trpCF hisD hisD hisG hisG impA impA hisC hisC Cgl2091 Cgl2091
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisAPHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. (246 aa)    
Predicted Functional Partners:
hisI
PROBABLE PHOSPHORIBOSYL-AMP CYCLOHYDROLASE PROTEIN; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
 0.999
hisF
PROBABLE CYCLASE (IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE-SUBUNIT); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
 
0.999
hisH
IMIDAZOLEGLYCEROL-PHOSPHATE SYNTHASE, AMIDOTRANSFERASE; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
 0.999
hisB
IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE.
 
  
 0.998
trpCF
INDOLE-3-GGLYCEROL-PHOSPHATE SYNTHASE/PHOSPHORIBOSYLANTHRANILATE ISOMERASE; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
  
 
 0.998
hisD
HISTIDINOL DEHYDROGENASE; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.996
hisG
ATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.994
impA
MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE FAMILY PROTEIN.
  
  
 0.992
hisC
PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.985
Cgl2091
Putative indole-3-glycerol phosphate synthase.
  
 
 0.984
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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