node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0616 | dinP | cg0713 | cg2355 | Conserved hypothetical protein. | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.797 |
Cgl0616 | dnaE2 | cg0713 | cg0738 | Conserved hypothetical protein. | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.933 |
Cgl0616 | lexA | cg0713 | cg2114 | Conserved hypothetical protein. | PUTATIVE LEXA REPRESSOR TRANSCRIPTION REGULATOR PROTEIN; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.521 |
dinF | dinP | cg2173 | cg2355 | PUTATIVE DNA-DAMAGE-INDUCIBLE MEMBRANE PROTEIN. | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.719 |
dinF | dnaE2 | cg2173 | cg0738 | PUTATIVE DNA-DAMAGE-INDUCIBLE MEMBRANE PROTEIN. | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.702 |
dinF | recA | cg2173 | cg2141 | PUTATIVE DNA-DAMAGE-INDUCIBLE MEMBRANE PROTEIN. | DNA RECOMBINATION/REPAIR; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.407 |
dinP | Cgl0616 | cg2355 | cg0713 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Conserved hypothetical protein. | 0.797 |
dinP | dinF | cg2355 | cg2173 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | PUTATIVE DNA-DAMAGE-INDUCIBLE MEMBRANE PROTEIN. | 0.719 |
dinP | dnaE2 | cg2355 | cg0738 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.973 |
dinP | dnaN | cg2355 | cg0004 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA POLYMERASE III, BETA SUBUNIT; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.922 |
dinP | lexA | cg2355 | cg2114 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | PUTATIVE LEXA REPRESSOR TRANSCRIPTION REGULATOR PROTEIN; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.956 |
dinP | mutY | cg2355 | cg2955 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | A/G-SPECIFIC ADENINE GLYCOSYLASE. | 0.734 |
dinP | ogt | cg2355 | cg3331 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.782 |
dinP | polA | cg2355 | cg1525 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA POLYMERASE I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.755 |
dinP | recA | cg2355 | cg2141 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA RECOMBINATION/REPAIR; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.962 |
dinP | uvrB | cg2355 | cg1550 | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | EXCINUCLEASE ABC SUBUNIT B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.798 |
dnaE2 | Cgl0616 | cg0738 | cg0713 | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Conserved hypothetical protein. | 0.933 |
dnaE2 | dinF | cg0738 | cg2173 | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | PUTATIVE DNA-DAMAGE-INDUCIBLE MEMBRANE PROTEIN. | 0.702 |
dnaE2 | dinP | cg0738 | cg2355 | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.973 |
dnaE2 | dnaN | cg0738 | cg0004 | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | DNA POLYMERASE III, BETA SUBUNIT; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.791 |