node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0839 | Cgl2786 | cg0961 | cg3086 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Putative L,L-Cystathionine gamma-Lyase. | 0.973 |
Cgl0839 | glyA | cg0961 | cg1133 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.816 |
Cgl0839 | metB | cg0961 | cg2687 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine gamma-Synthase. | 0.973 |
Cgl0839 | metE | cg0961 | cg1290 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.732 |
Cgl0839 | metF | cg0961 | cg2383 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.751 |
Cgl0839 | metH | cg0961 | cg1701 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.475 |
Cgl2786 | Cgl0839 | cg3086 | cg0961 | Putative L,L-Cystathionine gamma-Lyase. | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 0.973 |
Cgl2786 | metB | cg3086 | cg2687 | Putative L,L-Cystathionine gamma-Lyase. | Cystathionine gamma-Synthase. | 0.927 |
Cgl2786 | metE | cg3086 | cg1290 | Putative L,L-Cystathionine gamma-Lyase. | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.961 |
Cgl2786 | metF | cg3086 | cg2383 | Putative L,L-Cystathionine gamma-Lyase. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.915 |
Cgl2786 | metH | cg3086 | cg1701 | Putative L,L-Cystathionine gamma-Lyase. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.973 |
Cgl2786 | metK | cg3086 | cg1806 | Putative L,L-Cystathionine gamma-Lyase. | S-Adenosylmethionine Synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.488 |
folD | glyA | cg0750 | cg1133 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
folD | metF | cg0750 | cg2383 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.972 |
folD | metH | cg0750 | cg1701 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.652 |
folD | thyA | cg0750 | cg0966 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.930 |
folD | thyX | cg0750 | cg2162 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.914 |
glyA | Cgl0839 | cg1133 | cg0961 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 0.816 |
glyA | folD | cg1133 | cg0750 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
glyA | metF | cg1133 | cg2383 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-Methylenetetrahydrofolate Reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.977 |