STRINGSTRING
lipA lipA lipB lipB lplA lplA sucB sucB nadA nadA folE folE Cgl2210 Cgl2210 lpd lpd Cgl2311 Cgl2311 Cgl0147 Cgl0147 fixA fixA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lipALIPOIC ACID SYNTHASE; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (348 aa)    
Predicted Functional Partners:
lipB
LIPOATE-PROTEIN LIGASE B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
lplA
LIPOATE-PROTEIN LIGASE.
  
 
 0.971
sucB
DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family.
 
  
 0.851
nadA
QUINOLINATE SYNTHETASE; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
      
 0.829
folE
GTP CYCLOHYDROLASE.
     
 0.681
Cgl2210
Putative membrane protein.
       0.641
lpd
DIHYDROLIPOAMIDE DEHYDROGENASE; Lipoamide dehydrogenase is an essential component of the pyruvate dehydrogenase (PDH) and 2-oxoglutarate dehydrogenase (ODH) complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Also catalyzes a reversible NADH:NAD(+) transhydrogenation, and is able to transfer electrons from NADH to various redox-active compounds and quinones. May be involved in quinone redox cycling in C.glutamicum.
  
 0.627
Cgl2311
ALKANAL MONOOXYGENASE ALPHA CHAIN.
   
  
 0.626
Cgl0147
CONSERVED HYPOTHETICAL PROTEIN.
  
  
 0.619
fixA
PUTATIVE ELECTRON TRANSFER FLAVOPROTEIN, BETA SUBUNIT.
   
  
 0.604
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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