node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0183 | nadE | cg0228 | cg2792 | SENSOR HISTIDINE KINASE OF TWO-COMPONENT SYSTEM, FRAGMENT. | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.695 |
Cgl0778 | Cgl2517 | cg0888 | cg2774 | NTP pyrophosphohydrolase. | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.917 |
Cgl0778 | cobB | cg0888 | cg0745 | NTP pyrophosphohydrolase. | Protein deacetylase, SIR2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | 0.917 |
Cgl0778 | nadC | cg0888 | cg1215 | NTP pyrophosphohydrolase. | PUTATIVE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE; Belongs to the NadC/ModD family. | 0.903 |
Cgl0778 | nadD | cg0888 | cg2584 | NTP pyrophosphohydrolase. | PUTATIVE NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.905 |
Cgl0778 | nadE | cg0888 | cg2792 | NTP pyrophosphohydrolase. | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.903 |
Cgl0778 | ppnK | cg0888 | cg1601 | NTP pyrophosphohydrolase. | POLY(P)/ATP-NAD KINASE; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.901 |
Cgl2517 | Cgl0778 | cg2774 | cg0888 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NTP pyrophosphohydrolase. | 0.917 |
Cgl2517 | nadA | cg2774 | cg1216 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | QUINOLINATE SYNTHETASE; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.620 |
Cgl2517 | nadC | cg2774 | cg1215 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | PUTATIVE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE; Belongs to the NadC/ModD family. | 0.987 |
Cgl2517 | nadD | cg2774 | cg2584 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | PUTATIVE NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.974 |
Cgl2517 | nadE | cg2774 | cg2792 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.734 |
Cgl2517 | ppnK | cg2774 | cg1601 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | POLY(P)/ATP-NAD KINASE; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.515 |
bioA | bioB | cg2885 | cg0095 | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | BIOTIN SYNTHASE; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.999 |
bioA | nadE | cg2885 | cg2792 | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.701 |
bioB | bioA | cg0095 | cg2885 | BIOTIN SYNTHASE; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.999 |
bioB | nadA | cg0095 | cg1216 | BIOTIN SYNTHASE; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | QUINOLINATE SYNTHETASE; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.485 |
bioB | nadE | cg0095 | cg2792 | BIOTIN SYNTHASE; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.669 |
cobB | Cgl0778 | cg0745 | cg0888 | Protein deacetylase, SIR2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | NTP pyrophosphohydrolase. | 0.917 |
cobB | nadD | cg0745 | cg2584 | Protein deacetylase, SIR2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | PUTATIVE NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.941 |