node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
actA | mcmB | cg2840 | cg1725 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | 0.914 |
actA | odhA | cg2840 | cg1280 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | 0.437 |
actA | prpB1 | cg2840 | cg0797 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | PROBABLE METHYLISOCITRIC ACID LYASE; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. | 0.808 |
actA | prpB2 | cg2840 | cg0760 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | PROBABLE METHYLISOCITRIC ACID LYASE; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate; Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.809 |
actA | sdhA | cg2840 | cg0446 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | Succinate dehydrogenase A. | 0.907 |
actA | sdhB | cg2840 | cg0447 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | Succinate dehydrogenase B. | 0.913 |
actA | sdhCD | cg2840 | cg0445 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | Succinate dehydrogenase CD. | 0.900 |
actA | sucB | cg2840 | cg2421 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family. | 0.915 |
actA | sucC | cg2840 | cg2837 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | SUCCINYL-COA SYNTHETASE BETA SUBUNIT; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.930 |
actA | sucD | cg2840 | cg2836 | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | SUCCINYL-COA SYNTHETASE ALPHA SUBUNIT; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.927 |
mcmB | actA | cg1725 | cg2840 | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | 0.914 |
mcmB | odhA | cg1725 | cg1280 | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | 0.536 |
mcmB | sucB | cg1725 | cg2421 | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family. | 0.828 |
mcmB | sucC | cg1725 | cg2837 | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | SUCCINYL-COA SYNTHETASE BETA SUBUNIT; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.936 |
mcmB | sucD | cg1725 | cg2836 | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | SUCCINYL-COA SYNTHETASE ALPHA SUBUNIT; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.941 |
odhA | actA | cg1280 | cg2840 | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | BUTYRYL-COA:ACETATE COENZYME A TRANSFERASE. | 0.437 |
odhA | mcmB | cg1280 | cg1725 | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | METHYLMALONYL-COA MUTASE LARGE SUBUNIT. | 0.536 |
odhA | sdhA | cg1280 | cg0446 | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | Succinate dehydrogenase A. | 0.955 |
odhA | sdhB | cg1280 | cg0447 | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | Succinate dehydrogenase B. | 0.972 |
odhA | sucB | cg1280 | cg2421 | 2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. | DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family. | 0.999 |