STRINGSTRING
cntO cntO cntM cntM cntL cntL cntI cntI PA4838 PA4838 rpmE2 rpmE2 PA0781 PA0781 PA5535 PA5535 PA4063 PA4063 PA4066 PA4066 dksA-2 dksA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
cntOProbable outer membrane protein precursor; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the import of pseudopaline-metal complexes. Belongs to the TonB-dependent receptor family. (708 aa)    
Predicted Functional Partners:
cntM
Hypothetical protein; Catalyzes the NAD(P)H-dependent reductive condensation of alpha-ketoglutarate to the intermediate formed by the adjacently encoded enzyme PA4836, namely (2S)-2-amino-4- pseudopaline. This is the last step in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Can use neither pyruvate nor oxaloacetate in place of alpha-ketoglutarate. Is two-fold more efficient [...]
  
  
 0.994
cntL
Hypothetical protein; Catalyzes the nucleophilic attack of one alpha-aminobutanoate moiety from SAM onto L-histidine to produce the intermediate (2S)-2- amino-4- Functions in the biosynthesis of the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to Pseudomonas virulence. Appears to be specific for L-histidine as substrate. Belongs to the methyltransferase superfamily. CntL family.
  
  
 0.994
cntI
Hypothetical protein; Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS) ; Belongs to the EamA transporter family.
  
  
 0.991
PA4838
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.991
rpmE2
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.981
PA0781
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
  
 0.966
PA5535
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.950
PA4063
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.948
PA4066
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.923
dksA-2
Conserved hypothetical protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.
   
  
 0.903
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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