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There are several matches for 'collagenase'.
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2716 matches
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protein
1)
Homo sapiens
TIMP1 - Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as
collagenases
, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...]
[a.k.a. TIMP, Q6FGX5, TIMP metallopeptidase inhibitor 1]
2)
Homo sapiens
MMP2 - 72 kDa type IV
collagenase
; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...]
[a.k.a. MMP2-207, ENST00000568715, Gelatinase A]
3)
Homo sapiens
MMP8 - Neutrophil
collagenase
; Can degrade fibrillar type I, II, and III collagens; Belongs to the peptidase M10A family.
[a.k.a. 3TT4, MMP8_HUMAN, ENSP00000440388]
4)
Homo sapiens
MMP13 -
Collagenase
3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]
[a.k.a. CLG3, 3WV2, AK315341]
5)
Homo sapiens
TIMP2 - Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as
collagenases
) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Belongs to the protease inhibitor I35 (TIMP) family.
[a.k.a. 7077, CSC-21K, ENSP00000262768]
6)
Homo sapiens
IL1A - Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and
collagenase
from synovial cells.
[a.k.a. 2ILA, CCDS2101.1, ENSG00000115008]
7)
Homo sapiens
TIMP3 - Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as
collagenases
) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
[a.k.a. U38952, ENST00000538671, TIMP-3]
8)
Homo sapiens
SETD7 - Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as
collagenase
or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys- 1 [...]
[a.k.a. Q4W5A9, URS0000E9A76E, 5AYF]
9)
Homo sapiens
TIMP4 - Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as
collagenases
) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
[a.k.a. NX_Q99727, uc003bwo.4, tissue inhibitor of metalloproteinase 4]
10)
Homo sapiens
ITGA2 - Integrin alpha-2; Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and
collagenase
gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
[a.k.a. UPI0001D3B2ED, CD49B, R-HSA-6806834]
11)
Homo sapiens
PLG - Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator,
collagenases
and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]
[a.k.a. 3.4.21.7, ENST00000428851, 4DUR]
12)
Homo sapiens
MMP1 - 22 kDa interstitial
collagenase
; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
[a.k.a. R-HSA-202733, 4AUO, CLG]
13)
Homo sapiens
ELF3 - ETS-related transcription factor Elf-3; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates
collagenase
, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effec [...]
[a.k.a. NP_004424.3, R-HSA-162582, CAG33387.1]
14)
Homo sapiens
DDR2 - Discoidin domain-containing receptor 2; Tyrosine kinase involved in the regulation of tissues remodeling. It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the
collagenases
MMP1, MM [...]
[a.k.a. UPI000013E1B4, Tyrosine-protein kinase TYRO10, TYRO10]
15)
Mus musculus
Elf3 - ETS-related transcription factor Elf-3; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates
collagenase
, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. Ma [...]
[a.k.a. R-MMU-157118, ESE-1, NM_001163131]
16)
Mus musculus
Plg - Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator,
collagenases
and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]
[a.k.a. 3.4.21.7, R-MMU-186797, ENSMUSP00000014578]
17)
Mus musculus
Mmp13 -
Collagenase
3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]
[a.k.a. BAE29805.1, M10.013, Matrix metalloproteinase-13]
18)
Mus musculus
Timp2 - Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as
collagenases
) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.
[a.k.a. Timp2-202, ENSMUSP00000017610, NM_011594.3]
19)
Mus musculus
Mmp8 - Neutrophil
collagenase
; Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.
[a.k.a. Collagenase-2, 17394, Mmp8-201]
20)
Mus musculus
Timp3 - Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as
collagenases
) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
[a.k.a. Timp-3, TIMP-3, NM_011595.2]
2716 matches
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