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There are several matches for 'malE'.
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4942 matches
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protein
1)
Escherichia coli K12
malE
- Maltose transporter subunit; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. Belongs to the bacterial solute-binding protein 1 family.
2)
Homo sapiens
SLC26A8 - Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in
male
germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in
male
germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence
male
fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes [...]
[a.k.a. ENST00000490799, TAT1, ENSP00000347778]
3)
Homo sapiens
SRY - Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in
male
development. It is necessary and sufficient for initiating
male
sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In
male
adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partia [...]
[a.k.a. JQ811905, 2GZK, NM_003140.2]
4)
Homo sapiens
NANOS2 - Nanos homolog 2; Plays a key role in the sexual differentiation of germ cells by promoting the
male
fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the
male
fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for t [...]
[a.k.a. 339345, ENST00000341294.3, ENSP00000341021]
5)
Homo sapiens
SOX3 - Transcription factor SOX-3; Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in
male
development. Is necessary for initiating
male
sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By s [...]
[a.k.a. HPA075003, R-HSA-162582, R-HSA-195721]
6)
Homo sapiens
DMRT1 - Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in
male
sex determination and differentiation by controlling testis development and
male
germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...]
[a.k.a. XP_006716795.1, ENST00000382276.7, ENST00000382276]
7)
Homo sapiens
SYCP3 - Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in
male
germ cells (By similarity). Required for normal meiosis during spermatogenesis and
male
fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). Belongs to the XLR/SYCP3 family.
[a.k.a. ENSP00000266743, ENSP00000376658, R-HSA-1474165]
8)
Homo sapiens
RAD21L1 - Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in
male
meiosis. Probably required during early meiosis in
males
for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).
[a.k.a. RD21L_HUMAN, RAD21L, BC157891]
9)
Homo sapiens
YTHDC2 - 3'-5' RNA helicase YTHDC2; 3'-5' RNA helicase that plays a key role in the
male
and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non- coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6 [...]
[a.k.a. XP_011541883.1, NP_073739.3, ENSP00000296637]
10)
Homo sapiens
TRIP13 - Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In
males
, required for efficient synapsis of the sex chromosomes and for [...]
[a.k.a. O15324, 5WC2, NP_001159732.1]
11)
Homo sapiens
ADAM7 - Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in
male
reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).
[a.k.a. ENSP00000370166, NP_003808, AF215824]
12)
Homo sapiens
ROPN1 - Ropporin-1A; Important for
male
fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family.
[a.k.a. NR_133919.1, ENSP00000418470, R-HSA-162582]
13)
Homo sapiens
HSPB11 - Intraflagellar transport protein 25 homolog; Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for
male
ferti [...]
[a.k.a. HPA030140, ENST00000371377.3, C1orf41]
14)
Homo sapiens
GAPDHS - Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and
male
fertility (By similarity).
[a.k.a. BC036373, 5C7L, AF216641]
15)
Homo sapiens
GORASP2 - Golgi reassembly-stacking protein 2; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal
male
fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER [...]
[a.k.a. ENST00000488928, ENST00000471559, R-HSA-69278]
16)
Homo sapiens
SPACA1 - Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for
male
fertility.
[a.k.a. SAMP32, ENSP00000237201, Q9HBV2]
17)
Homo sapiens
TEX14 - Inactive serine/threonine-protein kinase TEX14; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and
male
fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodie [...]
[a.k.a. Q8IWB6, TEX14-205, ENST00000581147]
18)
Homo sapiens
DAZL - Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both
males
and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity); Belongs to the RRM DAZ family.
[a.k.a. AAC50813.1, A0A140VK77, UPI0000412129]
19)
Homo sapiens
IQCG - Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for
male
fertility.
[a.k.a. XR_002959601.1, ENSP00000393743, URS00008BB6F0]
20)
Homo sapiens
SPATA9 - Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in
male
infertility.
[a.k.a. SPATA9-202, ENST00000395899, XR_001742295.1]
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