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20126 matches
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protein
1)
Escherichia coli K12
map
- Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
2)
Homo sapiens
SGSM3 - Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells.
[a.k.a. NM_001350042, BC008078, SGSM3_HUMAN,
MAP
]
3)
Homo sapiens
MLN - Motilin-associated peptide; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
[a.k.a. R-HSA-388396, HPA069392, R-HSA-162582,
MAP
]
4)
Homo sapiens
FLRT1 - Leucine-rich repeat transmembrane protein FLRT1; Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of
MAP
kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream
MAP
kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
[a.k.a. NP_037412.2, R-HSA-190236, Leucine-rich repeat transmembrane protein FLRT1]
5)
Homo sapiens
DUSP26 - Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits
MAP
kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of
MAP
kinase p38 and c-Jun N-terminal kinase (JNK).
[a.k.a. 3.1.3.16, NM_024025.3, HPA018221]
6)
Homo sapiens
MAP2K2 - Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in
MAP
kinases. Activates the ERK1 and ERK2
MAP
kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
[a.k.a. NM_030662, ENST00000394867, OTTHUMG00000134286]
7)
Homo sapiens
DUSP6 - Dual specificity protein phosphatase 6; Inactivates
MAP
kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and
MAP
kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/ [...]
[a.k.a. 3.1.3.16, PYST1, CCDS9034]
8)
Homo sapiens
MADD -
MAP
kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with
MAP
kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is res [...]
[a.k.a. NP_569832, Q8IWD7, UPI000013E874]
9)
Homo sapiens
MAP2K3 - Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the
MAP
kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
MAP
kinase kinase subfamily.
[a.k.a. MAPKK 3, ENST00000479129.5, ENSP00000434068]
10)
Homo sapiens
MAPKAPK2 -
MAP
kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by
MAP
kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...]
[a.k.a. OMIM:602006, ENST00000479009, BC052584]
11)
Homo sapiens
MAPKAPK3 -
MAP
kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by
MAP
kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to [...]
[a.k.a. NX_Q16644, Q16644, R-HSA-162582]
12)
Homo sapiens
PPP2CA - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (
MAPs
). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and
MAP
-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
[a.k.a. 3.1.3.16, R-HSA-2555396, R-HSA-388396]
13)
Homo sapiens
PBK - Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates
MAP
kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
MAP
kinase kinase subfamily.
[a.k.a. ENSP00000428489, CCDS64858, CCDS64858.1]
14)
Homo sapiens
MAP2K6 - Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the
MAP
kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the
MAP
kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 i [...]
[a.k.a. PRKMK6, ENST00000592348, MAPKK6]
15)
Homo sapiens
DUSP14 - Dual specificity protein phosphatase 14; Involved in the inactivation of
MAP
kinases. Dephosphorylates ERK, JNK and p38
MAP
-kinases; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
[a.k.a. 3.1.3.16, CCDS11320, CR541800]
16)
Homo sapiens
CARD14 - Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK
MAP
kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK
MAP
kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
[a.k.a. XP_024306703, ENSG00000141527, UPI000013D81B]
17)
Homo sapiens
STYK1 - Tyrosine-protein kinase STYK1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both
MAP
kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
[a.k.a. AF251059, STYK1_HUMAN, NX_Q6J9G0]
18)
Homo sapiens
TRIB2 - Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of
MAP
kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
[a.k.a. C5FW, AAH02637.1, AC009486]
19)
Homo sapiens
MAPK13 - Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the
MAP
kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...]
[a.k.a. Y10488, ENSP00000362871, XM_024446491]
20)
Homo sapiens
MAPK12 - Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the
MAP
kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...]
[a.k.a. ENST00000395780.5, Mitogen-activated protein kinase p38 gamma, P38 MAP kinase]
20126 matches
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