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3267 matches
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protein
1)
Homo sapiens
PCNA
- Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...]
2)
Mus musculus
Pcna
- Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...]
3)
Drosophila melanogaster
PCNA
- Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the
PCNA
family.
4)
Caenorhabditis elegans
pcn-1 - Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the
PCNA
family.
[a.k.a. W03D2.4, Proliferating cell nuclear antigen, 177161,
PCNA
]
5)
Saccharomyces cerevisiae
POL30 - Proliferating cell nuclear antigen (
PCNA
); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair;
PCNA
ubiquitination at K164 plays a crucial role during Okazaki fragment processing.
[a.k.a. YBR088C, 5T9D, 3L10,
PCNA
]
6)
Homo sapiens
SPRTN - SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated
PCNA
that enhances RAD18-mediated
PCNA
ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated
PCNA
and RAD18, the E3 ubiquitin ligase that monoubiquitinates
PCNA
. Facilitates chromatin association of RAD18 and is required for efficient
PCNA
monoubiquitination, promoting a feed-forward loop to enhance
PCNA
ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...]
[a.k.a. 6MDW, Q96BC5, R-HSA-110320]
7)
Homo sapiens
SDE2 - Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with
PCNA
via its PIP- box. The interaction with
PCNA
prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to
PCNA
also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to
PCNA
is necessary to counteract dam [...]
[a.k.a. NP_689821, hsa:163859, ENSP00000355782]
8)
Homo sapiens
PCLAF -
PCNA
-associated factor;
PCNA
-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with
PCNA
is disrupted, facilitating the interaction between monoubiquitinated
PCNA
and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number.
[a.k.a. AEW89568.1, ENSP00000453527, AEW89518.1]
9)
Homo sapiens
CREBBP - CREB-binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non- histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates
PCNA
; acetylation promotes removal of chromatin-bound
PCNA
and it [...]
[a.k.a. NM_004380, OTTHUMG00000129431, 1WO4]
10)
Homo sapiens
USP1 - Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in
PCNA
-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated
PCNA
. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
[a.k.a. USP1-202, AAH18745.1, KF495964]
11)
Homo sapiens
RFC2 - Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (
PCNA
) and activator 1. This subunit binds ATP (By similarity).
[a.k.a. P35250, R-HSA-69278, R-HSA-69620]
12)
Homo sapiens
TNFAIP1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the
PCNA
- dependent DNA polymerase delta activity; Belongs to the BACURD family.
[a.k.a. hBACURD2, ENSP00000226225, B12]
13)
Homo sapiens
MLH1 - DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and
PCNA
is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...]
[a.k.a. U17843, MLH1-226, ENST00000673713]
14)
Homo sapiens
CHTF18 - Chromosome transmission fidelity protein 18 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (
PCNA
). The CTF18-RFC complex catalyzes the ATP- depen [...]
[a.k.a. ENST00000262315.13, ENSP00000262315, uc002cke.4]
15)
Homo sapiens
POLD3 - DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by
PCNA
. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences [...]
[a.k.a. ENSP00000432233, UPI00005DC72B, NP_001350526]
16)
Homo sapiens
ZRANB3 - DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated
PCNA
and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. [...]
[a.k.a. zinc finger, RAN-binding domain containing 3, ENST00000314539, Annealing helicase 2]
17)
Homo sapiens
RAD18 - E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated
PCNA
on 'Lys-164'. Has ssDNA binding activity.
[a.k.a. RAD18-201, NM_020165.4, NX_Q9NS91]
18)
Homo sapiens
PMS2 - Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and
PCNA
is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing th [...]
[a.k.a. NP_001308940.1, NM_001322010.1, P54278]
19)
Homo sapiens
SHPRH - E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of
PCNA
which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'; Belongs to the SNF2/RAD54 helicase family.
[a.k.a. XM_006715443.4, XP_006715504.1, SHPRH-202]
20)
Homo sapiens
HLTF - Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound
PCNA
.
[a.k.a. 4HRH, Q14527, NM_139048.2]
3267 matches
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