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There are several matches for 'polB'.
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946 matches
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protein
1)
Homo sapiens
POLB
- DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
2)
Mus musculus
Polb
- DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity).
3)
Escherichia coli K12
polB
- DNA polymerase II; Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
4)
Homo sapiens
POLG2 - DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
[a.k.a. polymerase (DNA) gamma 2, accessory subunit, ADP91704.1, BC009194,
POLB
]
5)
Homo sapiens
FAM168A - Protein FAM168A; In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing
POLB
degradation. Decreases
POLB
ubiquitation and stabilizes its protein levels.
[a.k.a. A2ID81, ENSP00000390501, NM_015159.3]
6)
Homo sapiens
HUS1 - Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (
POLB
) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes
POLB
to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...]
[a.k.a. ENSP00000416588, ENST00000258774, R-HSA-69620]
7)
Homo sapiens
RAD9A - protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (
POLB
) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes
POLB
to those sites where LP-BER proceeds; endonuclease FEN [...]
[a.k.a. RAD9A-208, ENSP00000444979, R-HSA-69620]
8)
Homo sapiens
RAD1 - RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (
POLB
) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes
POLB
to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...]
[a.k.a. R-HSA-69620, REC1, RAD1-206]
9)
Homo sapiens
USP47 - Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (
POLB
), stabilizing
POLB
thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
[a.k.a. NM_001372095.1, 55031, ENST00000540365]
10)
Homo sapiens
HUWE1 - E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (
POLB
) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and pro [...]
[a.k.a. XM_017029197, DQ097177, AB046798]
11)
Acanthochromis polyacanthus
polb
- DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
12)
Acidiplasma sp. MBA1
polB
- DNA polymerase II; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
13)
Aciduliprofundum boonei
polB
- DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
14)
Aciduliprofundum sp. MAR08339
polB
- Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
15)
Aeromonas bivalvium
polB
- DNA polymerase II.
16)
Aeromonas encheleia
polB
- Unannotated protein.
17)
Aeromonas hydrophila
polB
- DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.
18)
Aeromonas salmonicida
polB
- Unannotated protein.
19)
Aeromonas salmonicida masoucida
polB
- DNA polymerase II.
20)
Aeromonas schubertii
polB
- DNA polymerase II.
946 matches
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