STRINGSTRING
Tmem115 Tmem115 Cog2 Cog2 Cog1 Cog1 Cog4 Cog4 Cog8 Cog8 Cog7 Cog7 Cog3 Cog3 Cog6 Cog6 Cog5 Cog5 Cdc42 Cdc42 Mul1 Mul1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Tmem115Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. (350 aa)    
Predicted Functional Partners:
Cog2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function.
   
 
 0.822
Cog1
Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.
   
 
 0.801
Cog4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
   
 
 0.798
Cog8
Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.
   
 
 0.797
Cog7
Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function.
   
 
 0.795
Cog3
Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.
   
 
 0.783
Cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
 0.779
Cog5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function.
   
 
 0.778
Cdc42
Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Req [...]
     
  0.720
Mul1
Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'- linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (By similarity). Proposed to preferentially act as a SUMO E3 ligase at phys [...]
   
    0.666
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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