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Bzw2 Bzw2 Ankmy2 Ankmy2 Bzw1 Bzw1 Lrrc72 Lrrc72 Tspan13 Tspan13 Snx13 Snx13 Eif5 Eif5 Eif2s2 Eif2s2 Eif1 Eif1 Pom121l12 Pom121l12 Smpdl3b Smpdl3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Bzw2Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. (419 aa)    
Predicted Functional Partners:
Ankmy2
Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia.
   
  
 0.663
Bzw1
Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly; Belongs to the BZW family.
  
 
0.650
Lrrc72
Leucine-rich repeat-containing 72.
      
 0.586
Tspan13
Tetraspanin-13.
 
 
  
 0.580
Snx13
Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family.
      
 0.561
Eif5
Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]); Belongs to the eIF-2-beta/eIF-5 family.
   
 
 0.519
Eif2s2
Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...]
   
 
 0.490
Eif1
Eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity); Belongs to the SUI1 family.
   
  
 0.452
Pom121l12
POM121 membrane glycoprotein-like 12.
      
 0.432
Smpdl3b
Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) ; Belongs to the acid sphingomyelinase family.
   
  
 0.425
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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