node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cps1 | Dhodh | ENSMUSP00000027144 | ENSMUSP00000115934 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.773 |
Cps1 | Dpyd | ENSMUSP00000027144 | ENSMUSP00000039429 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | 0.747 |
Cps1 | Gart | ENSMUSP00000027144 | ENSMUSP00000023684 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.680 |
Cps1 | Gm28040 | ENSMUSP00000027144 | ENSMUSP00000142264 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Predicted gene, 28040. | 0.583 |
Cps1 | Golt1a | ENSMUSP00000027144 | ENSMUSP00000092136 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. | 0.617 |
Cps1 | Golt1b | ENSMUSP00000027144 | ENSMUSP00000032372 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. | 0.583 |
Cps1 | Kiss1 | ENSMUSP00000027144 | ENSMUSP00000007433 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Metastasis-suppressor KiSS-1; Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation [...] | 0.583 |
Cps1 | Slc23a1 | ENSMUSP00000027144 | ENSMUSP00000025212 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Solute carrier family 23 member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity); Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. | 0.600 |
Cps1 | Umps | ENSMUSP00000027144 | ENSMUSP00000023510 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family. | 0.851 |
Cps1 | Uox | ENSMUSP00000027144 | ENSMUSP00000029837 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. | 0.553 |
Dhodh | Cps1 | ENSMUSP00000115934 | ENSMUSP00000027144 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.773 |
Dhodh | Dpyd | ENSMUSP00000115934 | ENSMUSP00000039429 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | 0.490 |
Dhodh | Gart | ENSMUSP00000115934 | ENSMUSP00000023684 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.812 |
Dhodh | Gm28040 | ENSMUSP00000115934 | ENSMUSP00000142264 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Predicted gene, 28040. | 0.682 |
Dhodh | Golt1a | ENSMUSP00000115934 | ENSMUSP00000092136 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. | 0.682 |
Dhodh | Golt1b | ENSMUSP00000115934 | ENSMUSP00000032372 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. | 0.682 |
Dhodh | Kiss1 | ENSMUSP00000115934 | ENSMUSP00000007433 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Metastasis-suppressor KiSS-1; Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation [...] | 0.682 |
Dhodh | Slc23a1 | ENSMUSP00000115934 | ENSMUSP00000025212 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Solute carrier family 23 member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity); Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. | 0.630 |
Dhodh | Umps | ENSMUSP00000115934 | ENSMUSP00000023510 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family. | 0.998 |
Dpyd | Cps1 | ENSMUSP00000039429 | ENSMUSP00000027144 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | 0.747 |