node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr10 | Actr1a | ENSMUSP00000021479 | ENSMUSP00000039844 | Actin-related protein 10; Belongs to the actin family. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.998 |
Actr10 | Actr1b | ENSMUSP00000021479 | ENSMUSP00000047326 | Actin-related protein 10; Belongs to the actin family. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity); Belongs to the actin family. ARP1 subfamily. | 0.981 |
Actr10 | Bicd2 | ENSMUSP00000021479 | ENSMUSP00000039394 | Actin-related protein 10; Belongs to the actin family. | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport via i [...] | 0.745 |
Actr10 | Dctn1 | ENSMUSP00000021479 | ENSMUSP00000109552 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
Actr10 | Dctn2 | ENSMUSP00000021479 | ENSMUSP00000026479 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr10 | Dctn3 | ENSMUSP00000021479 | ENSMUSP00000030158 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.994 |
Actr10 | Dctn4 | ENSMUSP00000021479 | ENSMUSP00000025505 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.999 |
Actr10 | Dctn5 | ENSMUSP00000021479 | ENSMUSP00000033156 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.999 |
Actr10 | Dctn6 | ENSMUSP00000021479 | ENSMUSP00000113716 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. | 0.999 |
Actr10 | Dync1i1 | ENSMUSP00000021479 | ENSMUSP00000111221 | Actin-related protein 10; Belongs to the actin family. | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] | 0.825 |
Actr1a | Actr10 | ENSMUSP00000039844 | ENSMUSP00000021479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Actin-related protein 10; Belongs to the actin family. | 0.998 |
Actr1a | Actr1b | ENSMUSP00000039844 | ENSMUSP00000047326 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity); Belongs to the actin family. ARP1 subfamily. | 0.981 |
Actr1a | Bicd2 | ENSMUSP00000039844 | ENSMUSP00000039394 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport via i [...] | 0.652 |
Actr1a | Dctn1 | ENSMUSP00000039844 | ENSMUSP00000109552 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.995 |
Actr1a | Dctn2 | ENSMUSP00000039844 | ENSMUSP00000026479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr1a | Dctn3 | ENSMUSP00000039844 | ENSMUSP00000030158 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.992 |
Actr1a | Dctn4 | ENSMUSP00000039844 | ENSMUSP00000025505 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.997 |
Actr1a | Dctn5 | ENSMUSP00000039844 | ENSMUSP00000033156 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.995 |
Actr1a | Dctn6 | ENSMUSP00000039844 | ENSMUSP00000113716 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. | 0.996 |
Actr1a | Dync1i1 | ENSMUSP00000039844 | ENSMUSP00000111221 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] | 0.660 |