node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adh1 | Aldh3a1 | ENSMUSP00000004232 | ENSMUSP00000019246 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light. | 0.954 |
Adh1 | Ces1d | ENSMUSP00000004232 | ENSMUSP00000034172 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | 0.529 |
Adh1 | Cyp2e1 | ENSMUSP00000004232 | ENSMUSP00000026552 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.979 |
Adh1 | Ugt1a1 | ENSMUSP00000004232 | ENSMUSP00000072803 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.725 |
Adh1 | Ugt2a3 | ENSMUSP00000004232 | ENSMUSP00000031195 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family. | 0.732 |
Adh1 | Ugt2b1 | ENSMUSP00000004232 | ENSMUSP00000031183 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.732 |
Adh1 | Ugt2b34 | ENSMUSP00000004232 | ENSMUSP00000031181 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.721 |
Adh1 | Ugt2b35 | ENSMUSP00000004232 | ENSMUSP00000031186 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.734 |
Adh1 | Ugt2b37 | ENSMUSP00000004232 | ENSMUSP00000075255 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.820 |
Aldh3a1 | Adh1 | ENSMUSP00000019246 | ENSMUSP00000004232 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light. | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | 0.954 |
Aldh3a1 | Cyp2e1 | ENSMUSP00000019246 | ENSMUSP00000026552 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.964 |
Ces1d | Adh1 | ENSMUSP00000034172 | ENSMUSP00000004232 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | 0.529 |
Ces1d | Cyp2e1 | ENSMUSP00000034172 | ENSMUSP00000026552 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.967 |
Ces1d | Ugt1a1 | ENSMUSP00000034172 | ENSMUSP00000072803 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.755 |
Ces1d | Ugt2a3 | ENSMUSP00000034172 | ENSMUSP00000031195 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family. | 0.742 |
Ces1d | Ugt2b1 | ENSMUSP00000034172 | ENSMUSP00000031183 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.763 |
Ces1d | Ugt2b34 | ENSMUSP00000034172 | ENSMUSP00000031181 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.744 |
Ces1d | Ugt2b35 | ENSMUSP00000034172 | ENSMUSP00000031186 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.745 |
Ces1d | Ugt2b37 | ENSMUSP00000034172 | ENSMUSP00000075255 | Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.742 |
Cyp2e1 | Adh1 | ENSMUSP00000026552 | ENSMUSP00000004232 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. | 0.979 |