STRINGSTRING
Dock4 Dock4 Fau Fau Elmo2 Elmo2 Rps11 Rps11 Rps6 Rps6 Rpl19 Rpl19 Rps3a1 Rps3a1 Rpl21 Rpl21 Rps7 Rps7 Rps24 Rps24 Rpl6 Rpl6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
Dock4Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP (By similarity). (1978 aa)    
Predicted Functional Partners:
Fau
Ubiquitin-like protein FUBI; Belongs to the ubiquitin family.
   
 
 0.994
Elmo2
Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
   
 0.981
Rps11
40S ribosomal protein S11.
  
 
 0.957
Rps6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
  
 
 0.953
Rpl19
60S ribosomal protein L19.
   
 
 0.952
Rps3a1
40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.
   
 
 0.952
Rpl21
60S ribosomal protein L21; Component of the large ribosomal subunit.
   
 
 0.951
Rps7
40S ribosomal protein S7; Required for rRNA maturation.
   
 
 0.951
Rps24
40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.
  
 
 0.950
Rpl6
60S ribosomal protein L6; Component of the large ribosomal subunit.
   
 
 0.949
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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