node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ampd2 | Cog4 | ENSMUSP00000077946 | ENSMUSP00000034203 | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | 0.409 |
Ampd2 | Eps8l3 | ENSMUSP00000077946 | ENSMUSP00000042004 | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.456 |
Ampd2 | Mtss2 | ENSMUSP00000077946 | ENSMUSP00000050211 | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.439 |
Ampd2 | Vac14 | ENSMUSP00000077946 | ENSMUSP00000034190 | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. | 0.430 |
Arhgef37 | Fchsd1 | ENSMUSP00000130560 | ENSMUSP00000047878 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.598 |
Arhgef37 | Mtss2 | ENSMUSP00000130560 | ENSMUSP00000050211 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.581 |
Arhgef38 | Fchsd1 | ENSMUSP00000124280 | ENSMUSP00000047878 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.493 |
Arhgef38 | Mtss2 | ENSMUSP00000124280 | ENSMUSP00000050211 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.444 |
Cog4 | Ampd2 | ENSMUSP00000034203 | ENSMUSP00000077946 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.409 |
Cog4 | Eps8l3 | ENSMUSP00000034203 | ENSMUSP00000042004 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Epidermal growth factor receptor kinase substrate 8-like protein 3. | 0.538 |
Cog4 | Mtss2 | ENSMUSP00000034203 | ENSMUSP00000050211 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.464 |
Cog4 | Sf3b3 | ENSMUSP00000034203 | ENSMUSP00000045073 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] | 0.525 |
Cog4 | Vac14 | ENSMUSP00000034203 | ENSMUSP00000034190 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. | 0.575 |
Eps8l3 | Ampd2 | ENSMUSP00000042004 | ENSMUSP00000077946 | Epidermal growth factor receptor kinase substrate 8-like protein 3. | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.456 |
Eps8l3 | Cog4 | ENSMUSP00000042004 | ENSMUSP00000034203 | Epidermal growth factor receptor kinase substrate 8-like protein 3. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | 0.538 |
Eps8l3 | Mtss2 | ENSMUSP00000042004 | ENSMUSP00000050211 | Epidermal growth factor receptor kinase substrate 8-like protein 3. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.575 |
Eps8l3 | Sf3b3 | ENSMUSP00000042004 | ENSMUSP00000045073 | Epidermal growth factor receptor kinase substrate 8-like protein 3. | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] | 0.441 |
Eps8l3 | Vac14 | ENSMUSP00000042004 | ENSMUSP00000034190 | Epidermal growth factor receptor kinase substrate 8-like protein 3. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. | 0.473 |
Fbxl12 | Mtss2 | ENSMUSP00000119124 | ENSMUSP00000050211 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. | 0.468 |
Fchsd1 | Arhgef37 | ENSMUSP00000047878 | ENSMUSP00000130560 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.598 |