node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cenpc1 | Clptm1 | ENSMUSP00000031170 | ENSMUSP00000051293 | Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | 0.515 |
Cenpc1 | Mad2l1 | ENSMUSP00000031170 | ENSMUSP00000112304 | Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity); Belongs to the MAD2 family. | 0.584 |
Clptm1 | Cenpc1 | ENSMUSP00000051293 | ENSMUSP00000031170 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. | 0.515 |
Clptm1 | Glg1 | ENSMUSP00000051293 | ENSMUSP00000131355 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). | 0.533 |
Clptm1 | Insyn1 | ENSMUSP00000051293 | ENSMUSP00000082800 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | 0.471 |
Clptm1 | Itm2c | ENSMUSP00000051293 | ENSMUSP00000027425 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. | 0.670 |
Clptm1 | Lhfpl4 | ENSMUSP00000051293 | ENSMUSP00000124470 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | 0.475 |
Clptm1 | Mad1l1 | ENSMUSP00000051293 | ENSMUSP00000031534 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. | 0.533 |
Clptm1 | Mad2l1 | ENSMUSP00000051293 | ENSMUSP00000112304 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity); Belongs to the MAD2 family. | 0.491 |
Clptm1 | Ppp2r1a | ENSMUSP00000051293 | ENSMUSP00000007708 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.506 |
Clptm1 | Tmem259 | ENSMUSP00000051293 | ENSMUSP00000056792 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. Belongs to the membralin family. | 0.575 |
Clptm1 | Ubac2 | ENSMUSP00000051293 | ENSMUSP00000043245 | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. | 0.497 |
Glg1 | Clptm1 | ENSMUSP00000131355 | ENSMUSP00000051293 | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | 0.533 |
Insyn1 | Clptm1 | ENSMUSP00000082800 | ENSMUSP00000051293 | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | 0.471 |
Insyn1 | Itm2c | ENSMUSP00000082800 | ENSMUSP00000027425 | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. | 0.480 |
Insyn1 | Lhfpl4 | ENSMUSP00000082800 | ENSMUSP00000124470 | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | 0.519 |
Itm2c | Clptm1 | ENSMUSP00000027425 | ENSMUSP00000051293 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | 0.670 |
Itm2c | Insyn1 | ENSMUSP00000027425 | ENSMUSP00000082800 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | 0.480 |
Lhfpl4 | Clptm1 | ENSMUSP00000124470 | ENSMUSP00000051293 | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development. | 0.475 |
Lhfpl4 | Insyn1 | ENSMUSP00000124470 | ENSMUSP00000082800 | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. | 0.519 |