node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ercc6 | Hmgn1 | ENSMUSP00000066256 | ENSMUSP00000061012 | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to [...] | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 0.918 |
Fau | Hmgn1 | ENSMUSP00000136358 | ENSMUSP00000061012 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 0.992 |
Fau | Rpl11 | ENSMUSP00000136358 | ENSMUSP00000099595 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Fau | Rpl23 | ENSMUSP00000136358 | ENSMUSP00000099435 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L23. | 0.999 |
Fau | Rpl23a | ENSMUSP00000136358 | ENSMUSP00000099541 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.999 |
Fau | Rpl31 | ENSMUSP00000136358 | ENSMUSP00000083722 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. | 0.999 |
Fau | Rpl6 | ENSMUSP00000136358 | ENSMUSP00000031617 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L6; Component of the large ribosomal subunit. | 0.999 |
Fau | Rps11 | ENSMUSP00000136358 | ENSMUSP00000003521 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 40S ribosomal protein S11. | 0.999 |
Fau | Rps15 | ENSMUSP00000136358 | ENSMUSP00000069004 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. | 0.999 |
Fau | Rps3 | ENSMUSP00000136358 | ENSMUSP00000032998 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] | 0.999 |
Hmgn1 | Ercc6 | ENSMUSP00000061012 | ENSMUSP00000066256 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to [...] | 0.918 |
Hmgn1 | Fau | ENSMUSP00000061012 | ENSMUSP00000136358 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 0.992 |
Hmgn1 | Rpl11 | ENSMUSP00000061012 | ENSMUSP00000099595 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.898 |
Hmgn1 | Rpl23 | ENSMUSP00000061012 | ENSMUSP00000099435 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 60S ribosomal protein L23. | 0.904 |
Hmgn1 | Rpl23a | ENSMUSP00000061012 | ENSMUSP00000099541 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.908 |
Hmgn1 | Rpl31 | ENSMUSP00000061012 | ENSMUSP00000083722 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 60S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. | 0.899 |
Hmgn1 | Rpl6 | ENSMUSP00000061012 | ENSMUSP00000031617 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 60S ribosomal protein L6; Component of the large ribosomal subunit. | 0.897 |
Hmgn1 | Rps11 | ENSMUSP00000061012 | ENSMUSP00000003521 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 40S ribosomal protein S11. | 0.905 |
Hmgn1 | Rps15 | ENSMUSP00000061012 | ENSMUSP00000069004 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. | 0.898 |
Hmgn1 | Rps3 | ENSMUSP00000061012 | ENSMUSP00000032998 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] | 0.907 |