STRINGSTRING
Slc10a5 Slc10a5 Slc10a7 Slc10a7 Entpd8 Entpd8 Olfr1336 Olfr1336 Olfr1156 Olfr1156 Slc35e4 Slc35e4 Olfr893 Olfr893 Olfr33 Olfr33 Olfr559 Olfr559 Slc51b Slc51b Txndc8 Txndc8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slc10a5Sodium/bile acid cotransporter 5. (434 aa)    
Predicted Functional Partners:
Slc10a7
Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate); Belongs to the bile a [...]
      
 0.783
Entpd8
Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
   
    0.572
Olfr1336
Olfactory receptor.
      
 0.538
Olfr1156
Olfactory receptor.
      
 0.538
Slc35e4
Solute carrier family 35 member E4; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily.
      
 0.536
Olfr893
Olfactory receptor.
      
 0.526
Olfr33
Olfactory receptor.
   
  
 0.525
Olfr559
Olfactory receptor.
   
  
 0.525
Slc51b
Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
   
  
 0.502
Txndc8
Thioredoxin domain-containing protein 8; May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity).
   
  
 0.438
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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