node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfap161 | Mesd | ENSMUSP00000011298 | ENSMUSP00000091768 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Belongs to the MESD family. | 0.500 |
Cfap161 | Tlnrd1 | ENSMUSP00000011298 | ENSMUSP00000091769 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.618 |
Ctnna1 | Ctnna2 | ENSMUSP00000049007 | ENSMUSP00000124376 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | 0.902 |
Ctnna1 | Ctnna3 | ENSMUSP00000049007 | ENSMUSP00000101080 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | 0.915 |
Ctnna1 | Tlnrd1 | ENSMUSP00000049007 | ENSMUSP00000091769 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.501 |
Ctnna1 | Vcl | ENSMUSP00000049007 | ENSMUSP00000022369 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.987 |
Ctnna1 | Vinac1 | ENSMUSP00000049007 | ENSMUSP00000123404 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Vinculin/alpha-catenin family member 1. | 0.540 |
Ctnna2 | Ctnna1 | ENSMUSP00000124376 | ENSMUSP00000049007 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.902 |
Ctnna2 | Ctnna3 | ENSMUSP00000124376 | ENSMUSP00000101080 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | 0.915 |
Ctnna2 | Tlnrd1 | ENSMUSP00000124376 | ENSMUSP00000091769 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.501 |
Ctnna2 | Vcl | ENSMUSP00000124376 | ENSMUSP00000022369 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.974 |
Ctnna2 | Vinac1 | ENSMUSP00000124376 | ENSMUSP00000123404 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Vinculin/alpha-catenin family member 1. | 0.540 |
Ctnna3 | Ctnna1 | ENSMUSP00000101080 | ENSMUSP00000049007 | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.915 |
Ctnna3 | Ctnna2 | ENSMUSP00000101080 | ENSMUSP00000124376 | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | 0.915 |
Ctnna3 | Tlnrd1 | ENSMUSP00000101080 | ENSMUSP00000091769 | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.501 |
Ctnna3 | Vcl | ENSMUSP00000101080 | ENSMUSP00000022369 | Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes. | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.978 |
Ctnnal1 | Tlnrd1 | ENSMUSP00000036487 | ENSMUSP00000091769 | Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.501 |
Ctnnal1 | Vcl | ENSMUSP00000036487 | ENSMUSP00000022369 | Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.513 |
Mesd | Cfap161 | ENSMUSP00000091768 | ENSMUSP00000011298 | LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Belongs to the MESD family. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.500 |
Mesd | Tlnrd1 | ENSMUSP00000091768 | ENSMUSP00000091769 | LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Belongs to the MESD family. | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. | 0.645 |