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rnr-1 rnr-1 rnr-2 rnr-2 ndk-1 ndk-1 dtmk-1 dtmk-1 dut-1 dut-1 let-754 let-754 R05G6.5 R05G6.5 ZK673.2 ZK673.2 E02H1.6 E02H1.6 guk-1 guk-1 mcm-5 mcm-5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rnr-1Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (788 aa)    
Predicted Functional Partners:
rnr-2
Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 0.998
ndk-1
Nucleoside diphosphate kinase; Belongs to the NDK family.
    
 0.988
dtmk-1
Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP.
  
 
 0.985
dut-1
Deoxyuridinetriphosphatase.
  
 
 0.984
let-754
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
  
 
 0.983
R05G6.5
Uncharacterized protein.
    
 0.983
ZK673.2
Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family.
    
 0.983
E02H1.6
Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily.
   
 
  0.982
guk-1
Guanylate kinase-like domain-containing protein.
  
 
 0.980
mcm-5
DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...]
   
 
 0.978
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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