node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F56E10.1 | hira-1 | F56E10.1b.1 | K10D2.1a.1 | Uncharacterized protein. | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | 0.973 |
F56E10.1 | hmg-12 | F56E10.1b.1 | Y17G7A.1.1 | Uncharacterized protein. | High mobility group protein I beta. | 0.499 |
F56E10.1 | unc-85 | F56E10.1b.1 | F10G7.3.1 | Uncharacterized protein. | Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | 0.918 |
car-1 | hmg-12 | Y18D10A.17.1 | Y17G7A.1.1 | Cytokinesis, Apoptosis, RNA-associated. | High mobility group protein I beta. | 0.616 |
cdc-48.1 | cdc-48.2 | C06A1.1.1 | C41C4.8.2 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] | 0.988 |
cdc-48.1 | hmg-12 | C06A1.1.1 | Y17G7A.1.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] | High mobility group protein I beta. | 0.688 |
cdc-48.2 | cdc-48.1 | C41C4.8.2 | C06A1.1.1 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] | 0.988 |
cdc-48.2 | hmg-12 | C41C4.8.2 | Y17G7A.1.1 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] | High mobility group protein I beta. | 0.675 |
csr-1 | hmg-12 | F20D12.1a.1 | Y17G7A.1.1 | Piwi domain-containing protein. | High mobility group protein I beta. | 0.726 |
csr-1 | prg-1 | F20D12.1a.1 | D2030.6.1 | Piwi domain-containing protein. | Piwi-like protein; Belongs to the argonaute family. | 0.512 |
csr-1 | taf-11.2 | F20D12.1a.1 | K10D3.3.1 | Piwi domain-containing protein. | TAFII28 domain-containing protein. | 0.718 |
hira-1 | F56E10.1 | K10D2.1a.1 | F56E10.1b.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | Uncharacterized protein. | 0.973 |
hira-1 | his-74 | K10D2.1a.1 | W05B10.1.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | 0.847 |
hira-1 | hmg-12 | K10D2.1a.1 | Y17G7A.1.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | High mobility group protein I beta. | 0.516 |
hira-1 | unc-85 | K10D2.1a.1 | F10G7.3.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | 0.992 |
his-74 | hira-1 | W05B10.1.1 | K10D2.1a.1 | Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | 0.847 |
his-74 | hmg-12 | W05B10.1.1 | Y17G7A.1.1 | Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | High mobility group protein I beta. | 0.525 |
his-74 | unc-85 | W05B10.1.1 | F10G7.3.1 | Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. | 0.491 |
hmg-12 | F56E10.1 | Y17G7A.1.1 | F56E10.1b.1 | High mobility group protein I beta. | Uncharacterized protein. | 0.499 |
hmg-12 | car-1 | Y17G7A.1.1 | Y18D10A.17.1 | High mobility group protein I beta. | Cytokinesis, Apoptosis, RNA-associated. | 0.616 |