STRINGSTRING
CD247 CD247 CD3E CD3E CD3D CD3D CD3G CD3G ZAP70 ZAP70 SYK SYK NCR3 NCR3 FYN FYN LOC745350 LOC745350 NCR1 NCR1 LCK LCK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD247CD247 isoform 2. (163 aa)    
Predicted Functional Partners:
CD3E
CD3E isoform 2.
   
 0.999
CD3D
CD3D isoform 1.
   
 0.999
CD3G
CD3G isoform 1.
   
 0.999
ZAP70
Tyrosine-protein kinase.
   
 0.999
SYK
Tyrosine-protein kinase.
   
 0.997
NCR3
Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.
   
 0.988
FYN
Tyrosine-protein kinase.
   
 0.981
LOC745350
FCGR3A isoform 2.
     
 0.978
NCR1
NCR1 isoform 1.
   
 0.976
LCK
Tyrosine-protein kinase.
   
 0.971
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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