node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC7 | BUD13 | ENSP00000245543 | ENSP00000260210 | Armadillo repeat containing 7. | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.929 |
ARMC7 | CWC22 | ENSP00000245543 | ENSP00000387006 | Armadillo repeat containing 7. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | 0.922 |
ARMC7 | CWC27 | ENSP00000245543 | ENSP00000370460 | Armadillo repeat containing 7. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.922 |
ARMC7 | DHX16 | ENSP00000245543 | ENSP00000365625 | Armadillo repeat containing 7. | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. | 0.925 |
ARMC7 | GPKOW | ENSP00000245543 | ENSP00000156109 | Armadillo repeat containing 7. | G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing. | 0.936 |
ARMC7 | PPIL2 | ENSP00000245543 | ENSP00000486725 | Armadillo repeat containing 7. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. | 0.943 |
ARMC7 | PRPF8 | ENSP00000245543 | ENSP00000460348 | Armadillo repeat containing 7. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.922 |
ARMC7 | RNF113A | ENSP00000245543 | ENSP00000360497 | Armadillo repeat containing 7. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.924 |
BUD13 | ARMC7 | ENSP00000260210 | ENSP00000245543 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Armadillo repeat containing 7. | 0.929 |
BUD13 | CWC22 | ENSP00000260210 | ENSP00000387006 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | 0.998 |
BUD13 | CWC27 | ENSP00000260210 | ENSP00000370460 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.997 |
BUD13 | DHX16 | ENSP00000260210 | ENSP00000365625 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. | 0.998 |
BUD13 | DHX38 | ENSP00000260210 | ENSP00000268482 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome. | 0.845 |
BUD13 | GPKOW | ENSP00000260210 | ENSP00000156109 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing. | 0.983 |
BUD13 | PPIL2 | ENSP00000260210 | ENSP00000486725 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. | 0.836 |
BUD13 | PRPF8 | ENSP00000260210 | ENSP00000460348 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.997 |
BUD13 | RNF113A | ENSP00000260210 | ENSP00000360497 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.997 |
CWC22 | ARMC7 | ENSP00000387006 | ENSP00000245543 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Armadillo repeat containing 7. | 0.922 |
CWC22 | BUD13 | ENSP00000387006 | ENSP00000260210 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.998 |
CWC22 | CWC27 | ENSP00000387006 | ENSP00000370460 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.999 |