node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLGAP2 | ERICH1 | ENSP00000489774 | ENSP00000262109 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family. | Glutamate-rich protein 1; Glutamate rich 1. | 0.466 |
DLGAP2 | FBXO25 | ENSP00000489774 | ENSP00000372274 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.456 |
DLGAP2 | ZNF596 | ENSP00000489774 | ENSP00000381613 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family. | Zinc finger protein 596; May be involved in transcriptional regulation. | 0.403 |
ERICH1 | DLGAP2 | ENSP00000262109 | ENSP00000489774 | Glutamate-rich protein 1; Glutamate rich 1. | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family. | 0.466 |
ERICH1 | ERICH6 | ENSP00000262109 | ENSP00000295910 | Glutamate-rich protein 1; Glutamate rich 1. | Glutamate-rich protein 6; Glutamate rich 6. | 0.505 |
ERICH1 | FAM118A | ENSP00000262109 | ENSP00000216214 | Glutamate-rich protein 1; Glutamate rich 1. | Protein FAM118A; Family with sequence similarity 118 member A. | 0.475 |
ERICH1 | FBXO25 | ENSP00000262109 | ENSP00000372274 | Glutamate-rich protein 1; Glutamate rich 1. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.581 |
ERICH1 | MIB2 | ENSP00000262109 | ENSP00000426103 | Glutamate-rich protein 1; Glutamate rich 1. | E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. | 0.461 |
ERICH1 | PAXIP1 | ENSP00000262109 | ENSP00000384048 | Glutamate-rich protein 1; Glutamate rich 1. | PAX-interacting protein 1; Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP [...] | 0.604 |
ERICH1 | TDRP | ENSP00000262109 | ENSP00000430325 | Glutamate-rich protein 1; Glutamate rich 1. | Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family. | 0.561 |
ERICH1 | TMEM131 | ENSP00000262109 | ENSP00000186436 | Glutamate-rich protein 1; Glutamate rich 1. | Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family. | 0.488 |
ERICH1 | TTC9B | ENSP00000262109 | ENSP00000311760 | Glutamate-rich protein 1; Glutamate rich 1. | Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family. | 0.464 |
ERICH1 | ZNF596 | ENSP00000262109 | ENSP00000381613 | Glutamate-rich protein 1; Glutamate rich 1. | Zinc finger protein 596; May be involved in transcriptional regulation. | 0.605 |
ERICH6 | ERICH1 | ENSP00000295910 | ENSP00000262109 | Glutamate-rich protein 6; Glutamate rich 6. | Glutamate-rich protein 1; Glutamate rich 1. | 0.505 |
FAM118A | ERICH1 | ENSP00000216214 | ENSP00000262109 | Protein FAM118A; Family with sequence similarity 118 member A. | Glutamate-rich protein 1; Glutamate rich 1. | 0.475 |
FBXO25 | DLGAP2 | ENSP00000372274 | ENSP00000489774 | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family. | 0.456 |
FBXO25 | ERICH1 | ENSP00000372274 | ENSP00000262109 | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | Glutamate-rich protein 1; Glutamate rich 1. | 0.581 |
FBXO25 | TDRP | ENSP00000372274 | ENSP00000430325 | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family. | 0.706 |
FBXO25 | ZNF596 | ENSP00000372274 | ENSP00000381613 | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | Zinc finger protein 596; May be involved in transcriptional regulation. | 0.607 |
MIB2 | ERICH1 | ENSP00000426103 | ENSP00000262109 | E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. | Glutamate-rich protein 1; Glutamate rich 1. | 0.461 |