node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPHD1 | C16orf54 | ENSP00000311447 | ENSP00000327506 | Aspartate beta-hydroxylase domain containing 1. | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | 0.803 |
ASPHD1 | DOC2A | ENSP00000311447 | ENSP00000482870 | Aspartate beta-hydroxylase domain containing 1. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.684 |
ASPHD1 | HIRIP3 | ENSP00000311447 | ENSP00000279392 | Aspartate beta-hydroxylase domain containing 1. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.693 |
ASPHD1 | KIF22 | ENSP00000311447 | ENSP00000160827 | Aspartate beta-hydroxylase domain containing 1. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.661 |
ASPHD1 | PAGR1 | ENSP00000311447 | ENSP00000326519 | Aspartate beta-hydroxylase domain containing 1. | PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...] | 0.634 |
ASPHD1 | SEZ6L2 | ENSP00000311447 | ENSP00000481917 | Aspartate beta-hydroxylase domain containing 1. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.869 |
C16orf54 | ASPHD1 | ENSP00000327506 | ENSP00000311447 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Aspartate beta-hydroxylase domain containing 1. | 0.803 |
C16orf54 | DOC2A | ENSP00000327506 | ENSP00000482870 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.600 |
C16orf54 | HIRIP3 | ENSP00000327506 | ENSP00000279392 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.664 |
C16orf54 | KIF22 | ENSP00000327506 | ENSP00000160827 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.542 |
C16orf54 | PAGR1 | ENSP00000327506 | ENSP00000326519 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...] | 0.594 |
C16orf54 | SEZ6L2 | ENSP00000327506 | ENSP00000481917 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.609 |
CSNK2A1 | CSNK2A2 | ENSP00000217244 | ENSP00000262506 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.993 |
CSNK2A1 | HIRIP3 | ENSP00000217244 | ENSP00000279392 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.698 |
CSNK2A2 | CSNK2A1 | ENSP00000262506 | ENSP00000217244 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | 0.993 |
CSNK2A2 | HIRIP3 | ENSP00000262506 | ENSP00000279392 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.720 |
DOC2A | ASPHD1 | ENSP00000482870 | ENSP00000311447 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Aspartate beta-hydroxylase domain containing 1. | 0.684 |
DOC2A | C16orf54 | ENSP00000482870 | ENSP00000327506 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | 0.600 |
DOC2A | HIRIP3 | ENSP00000482870 | ENSP00000279392 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.700 |
DOC2A | KIF22 | ENSP00000482870 | ENSP00000160827 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.608 |