node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYHR1 | LRRC14 | ENSP00000433769 | ENSP00000292524 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 0.568 |
CYHR1 | MFSD3 | ENSP00000433769 | ENSP00000301327 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Major facilitator superfamily domain containing 3. | 0.533 |
CYHR1 | MROH1 | ENSP00000433769 | ENSP00000435565 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Maestro heat like repeat family member 1. | 0.794 |
CYHR1 | PPP1R16A | ENSP00000433769 | ENSP00000292539 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.700 |
GPT | PPP1R16A | ENSP00000378408 | ENSP00000292539 | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.731 |
HSP90AA1 | HSP90AB1 | ENSP00000335153 | ENSP00000360609 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.997 |
HSP90AA1 | PPP1R16A | ENSP00000335153 | ENSP00000292539 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.768 |
HSP90AB1 | HSP90AA1 | ENSP00000360609 | ENSP00000335153 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.997 |
HSP90AB1 | PPP1R16A | ENSP00000360609 | ENSP00000292539 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.770 |
LRRC14 | CYHR1 | ENSP00000292524 | ENSP00000433769 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.568 |
LRRC14 | MFSD3 | ENSP00000292524 | ENSP00000301327 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | Major facilitator superfamily domain containing 3. | 0.601 |
LRRC14 | MROH1 | ENSP00000292524 | ENSP00000435565 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | Maestro heat like repeat family member 1. | 0.402 |
LRRC14 | PPP1R16A | ENSP00000292524 | ENSP00000292539 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.628 |
MFSD3 | CYHR1 | ENSP00000301327 | ENSP00000433769 | Major facilitator superfamily domain containing 3. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.533 |
MFSD3 | LRRC14 | ENSP00000301327 | ENSP00000292524 | Major facilitator superfamily domain containing 3. | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 0.601 |
MFSD3 | MROH1 | ENSP00000301327 | ENSP00000435565 | Major facilitator superfamily domain containing 3. | Maestro heat like repeat family member 1. | 0.496 |
MFSD3 | PPP1R16A | ENSP00000301327 | ENSP00000292539 | Major facilitator superfamily domain containing 3. | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. | 0.631 |
MROH1 | CYHR1 | ENSP00000435565 | ENSP00000433769 | Maestro heat like repeat family member 1. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.794 |
MROH1 | LRRC14 | ENSP00000435565 | ENSP00000292524 | Maestro heat like repeat family member 1. | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs to the PRAME family. LRRC14 subfamily. | 0.402 |
MROH1 | MFSD3 | ENSP00000435565 | ENSP00000301327 | Maestro heat like repeat family member 1. | Major facilitator superfamily domain containing 3. | 0.496 |