STRINGSTRING
KBTBD11 KBTBD11 FGD2 FGD2 ZNF596 ZNF596 ERICH1 ERICH1 OR4F21 OR4F21 CUL3 CUL3 TDRP TDRP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
KBTBD11Kelch repeat and BTB domain containing 11. (623 aa)    
Predicted Functional Partners:
FGD2
FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
      
 0.492
ZNF596
Zinc finger protein 596; May be involved in transcriptional regulation.
   
  
 0.474
ERICH1
Glutamate-rich protein 1; Glutamate rich 1.
   
  
 0.434
OR4F21
Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.432
CUL3
Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...]
   
 
 0.423
TDRP
Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.
   
  
 0.401
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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