node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTNNA2 | ZNF639 | ENSP00000384638 | ENSP00000325634 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.681 |
ELP6 | ZBTB25 | ENSP00000296149 | ENSP00000476746 | Elongator complex protein 6; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity). Belongs to the ELP6 family. | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | 0.727 |
ELP6 | ZNF639 | ENSP00000296149 | ENSP00000325634 | Elongator complex protein 6; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity). Belongs to the ELP6 family. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.669 |
HDAC1 | MBD3L1 | ENSP00000362649 | ENSP00000471575 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | 0.864 |
HDAC1 | ZBTB2 | ENSP00000362649 | ENSP00000323183 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | 0.657 |
HDAC1 | ZNF639 | ENSP00000362649 | ENSP00000325634 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.518 |
KRT33B | ZNF639 | ENSP00000251646 | ENSP00000325634 | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.511 |
MBD3L1 | HDAC1 | ENSP00000471575 | ENSP00000362649 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.864 |
MBD3L1 | ZBTB2 | ENSP00000471575 | ENSP00000323183 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | 0.693 |
MBD3L1 | ZNF639 | ENSP00000471575 | ENSP00000325634 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.488 |
RASSF8 | ZNF639 | ENSP00000384491 | ENSP00000325634 | Ras association domain family member 8. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.487 |
SCRN3 | ZNF639 | ENSP00000272732 | ENSP00000325634 | Secernin-3; Secernin 3. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.419 |
ZBTB2 | HDAC1 | ENSP00000323183 | ENSP00000362649 | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.657 |
ZBTB2 | MBD3L1 | ENSP00000323183 | ENSP00000471575 | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | 0.693 |
ZBTB2 | ZBTB25 | ENSP00000323183 | ENSP00000476746 | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | 0.546 |
ZBTB2 | ZNF639 | ENSP00000323183 | ENSP00000325634 | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.806 |
ZBTB25 | ELP6 | ENSP00000476746 | ENSP00000296149 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | Elongator complex protein 6; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity). Belongs to the ELP6 family. | 0.727 |
ZBTB25 | ZBTB2 | ENSP00000476746 | ENSP00000323183 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation. | 0.546 |
ZBTB25 | ZNF639 | ENSP00000476746 | ENSP00000325634 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.467 |
ZBTB5 | ZNF639 | ENSP00000307604 | ENSP00000325634 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |