node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5orf22 | C5orf51 | ENSP00000326879 | ENSP00000371061 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family. | 0.577 |
C5orf22 | ELOF1 | ENSP00000326879 | ENSP00000465765 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. | 0.599 |
C5orf22 | KLHL12 | ENSP00000326879 | ENSP00000356230 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | 0.535 |
C5orf22 | OSM | ENSP00000326879 | ENSP00000215781 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). Belongs to the LIF/OSM family. | 0.544 |
C5orf22 | PQBP1 | ENSP00000326879 | ENSP00000498362 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | 0.568 |
C5orf22 | RGS3 | ENSP00000326879 | ENSP00000363255 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases. | 0.539 |
C5orf22 | SAYSD1 | ENSP00000326879 | ENSP00000229903 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | SAYSVFN motif domain containing 1. | 0.594 |
C5orf22 | TPGS2 | ENSP00000326879 | ENSP00000464780 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | Tubulin polyglutamylase complex subunit 2. | 0.574 |
C5orf22 | TRMT13 | ENSP00000326879 | ENSP00000359160 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | tRNA:m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). | 0.579 |
C5orf22 | WBP11 | ENSP00000326879 | ENSP00000261167 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. | 0.708 |
C5orf51 | C5orf22 | ENSP00000371061 | ENSP00000326879 | UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family. | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | 0.577 |
C5orf51 | KLHL12 | ENSP00000371061 | ENSP00000356230 | UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family. | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | 0.461 |
ELOF1 | C5orf22 | ENSP00000465765 | ENSP00000326879 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | 0.599 |
ELOF1 | PQBP1 | ENSP00000465765 | ENSP00000498362 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | 0.456 |
KLHL12 | C5orf22 | ENSP00000356230 | ENSP00000326879 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | 0.535 |
KLHL12 | C5orf51 | ENSP00000356230 | ENSP00000371061 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family. | 0.461 |
OSM | C5orf22 | ENSP00000215781 | ENSP00000326879 | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). Belongs to the LIF/OSM family. | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | 0.544 |
PQBP1 | C5orf22 | ENSP00000498362 | ENSP00000326879 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family. | 0.568 |
PQBP1 | ELOF1 | ENSP00000498362 | ENSP00000465765 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. | 0.456 |
PQBP1 | WBP11 | ENSP00000498362 | ENSP00000261167 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. | 0.994 |