node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHNAK | AHNAK2 | ENSP00000367263 | ENSP00000353114 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | AHNAK nucleoprotein 2. | 0.944 |
AHNAK | ANXA2 | ENSP00000367263 | ENSP00000346032 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.999 |
AHNAK | CAPN1 | ENSP00000367263 | ENSP00000431984 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. | 0.813 |
AHNAK | CAPN3 | ENSP00000367263 | ENSP00000380349 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.807 |
AHNAK | DYSF | ENSP00000367263 | ENSP00000386881 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.982 |
AHNAK | EZR | ENSP00000367263 | ENSP00000338934 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. | 0.958 |
AHNAK | MYOF | ENSP00000367263 | ENSP00000352208 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). | 0.849 |
AHNAK | PPL | ENSP00000367263 | ENSP00000340510 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Belongs to the plakin or cytolinker family. | 0.963 |
AHNAK | PRX | ENSP00000367263 | ENSP00000326018 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. [...] | 0.941 |
AHNAK | S100A10 | ENSP00000367263 | ENSP00000357801 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.999 |
AHNAK2 | AHNAK | ENSP00000353114 | ENSP00000367263 | AHNAK nucleoprotein 2. | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | 0.944 |
AHNAK2 | ANXA2 | ENSP00000353114 | ENSP00000346032 | AHNAK nucleoprotein 2. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.971 |
AHNAK2 | CAPN3 | ENSP00000353114 | ENSP00000380349 | AHNAK nucleoprotein 2. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.455 |
AHNAK2 | DYSF | ENSP00000353114 | ENSP00000386881 | AHNAK nucleoprotein 2. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.501 |
AHNAK2 | MYOF | ENSP00000353114 | ENSP00000352208 | AHNAK nucleoprotein 2. | Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). | 0.536 |
AHNAK2 | S100A10 | ENSP00000353114 | ENSP00000357801 | AHNAK nucleoprotein 2. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.949 |
ANXA2 | AHNAK | ENSP00000346032 | ENSP00000367263 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | 0.999 |
ANXA2 | AHNAK2 | ENSP00000346032 | ENSP00000353114 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | AHNAK nucleoprotein 2. | 0.971 |
ANXA2 | CAPN3 | ENSP00000346032 | ENSP00000380349 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.524 |
ANXA2 | DYSF | ENSP00000346032 | ENSP00000386881 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.989 |